IMB

IMB (Intestinal Microbiome Bank)

Using stool of healthy person, investigating an effective microorganism to
human and preparing the FMT samples

Stool Sample > Beneticial Microbiome & FMT Sample

Consortium

CKDBiO organized R&D network with Institutes of Green Bio Science & Technology of Seoul National University and the consortium is collaborating to construct intestinal microbiome library and advanced research of microbiome.

IMB Intestinal Microbiome Bank : CKDBio - Production researchCommercialization. GBST (SNU) - Microbiome Analysis Functionality research (in vitro, in vivo). SNUH (Gastroenterology Dept.) - Recruiting stool donor Collecting stool sample Clinical trials.

FMT (Fecal Microbiota Transplantation)

FMT is the process of transplantation of fecal bacteria from a healthy individual into a recipient.
FMT can be used to treat CDI (Clostridium difficile infection) effectively as a public therapeutics
(by Ministry of Health and Welfare Notice No.2016-87).

CDI pathogenesis

① Antibiotics abuse
               ↓
② Reduction of harmful/useful bacteria
               ↓
③ Microbiome imbalance
               ↓
④ Overgrowth of harmful bacteria
     (ex. C. difficile)

CDI pathogenesis

CDI symptom and treatment

Diarrhea, pyrexy, nausea, and stomachache are induced and  if symtoms are severe, proctocolectomy is sometimes performed for treatment. Although antibiotics is prescribed for treatment, CDI cure is too difficult and has high recurrence rate due to antibiotics-resistance of C. difficile.

CDI treatment through FMT

FMT, fecal bacteria from a healthy individual into a CDI patient for microbiome recover, is developed as a new treatment of CDI. It is showing a high treatment success rate more than 90% against recurrent CDI.

CDI treatment through FMT